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教师简介

教师简介

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刘晓丽

个人简介:

刘晓丽,女,赌钱平台官网教授,博导,2016年首届博士后创新人才计划获得者,陕西省级人才。

在过去5年分别在包括十大赌博官方正规网站、清华大学、新加坡国立大学以及国家纳米科学中心受到多学科纳米生物科研实践训练,主要研究生物磁性纳米材料的制备以及调控其尺寸、形貌、组成和表面修饰实现其生物医学应用性能的提高,发展生物安全性诊疗一体化磁性纳米探针在肿瘤诊断和治疗中的应用。迄今为止,在本学科方向共发表SCI论文50余篇,他引1000余次。以第一作者/通讯作者发表SCI论文30篇,其中IF>8的权威期刊论文12篇,包括Adv. Mater. (IF=25.809, 3), ACS Nano (IF=13.903, 2), Nano Lett. (IF=12.279, 2), Biomaterials (IF=10.273, 1) 等。授权专利2项。主持国家及省部科研项目3项。2019年荣获陕西省自然科学奖一等奖项目(第4完成人)。《Journal of Chinese medicine science》建议编委会杂志编委。担任中国生物材料学会纳米生物材料分会第二届委员会委员,中日医学科技交流协会第二届热疗专业委员会委员,中国生物物理学会纳米生物学分会青年委员。


获奖情况及荣誉:

1.陕西省自然科学奖一等奖,2019年

2.陕西省教育厅, 科技进步, 省部一等奖, 2016年

主要课题:

主要从事磁纳米生物材料及纳米生物学和纳米医学研究,致力于设计高性能磁性纳米生物材料,利用其纳米磁热效应,将其发展成为在纳米尺度认知和调控生命体系的工具,最终实现从分子相互作用,细胞功能和命运,到重大疾病治疗可视化、精准的调控。具体如下:

1.在保证安全性的前提下,突破超顺磁尺寸对磁学性能的限制,构建了一系列新型、高性能纳米铁氧体材料。

2.申请者通过在复杂生物体系内分子、细胞、组织多层次磁热生物效应研究,发展了高效抗肿瘤纳米磁热治疗。

3. 针对抗肿瘤多模式联合疗法,利用纳米磁热效应,在乳腺癌转移瘤综合治疗中解决免疫治疗、化疗等耐受问题。

近年来主要成果:

2020

1. Xiaoli Liu#; Bin Yan#; Yao Li; Xiaowei Ma; Wangbo Jiao; Kejian Shi; Tingbin Zhang; Shizhu Chen; Yuan He; Xing-Jie Liang; Haiming Fan*. Graphene oxide-grafted magnetic nanorings mediated magnetothermodynamic therapy favoring reactive oxygen species-related immune response for enhanced antitumor efficacy. ACS Nano, 2020, 14(2): 1936-1950. IF=13.903 SCI一区

2. Xiaoli Liu#; Yifan Zhang#; Yanyun Wang; Wenjing Zhu; Galong Li; Xiaowei Ma; Yihan Zhang; Shizhu Chen; Shivani Tiwari; Kejian Shi; Shouwen Zhang; Hai Ming Fan*; Yong Xiang Zhao; Xing-Jie Liang*.Comprehensive understanding of magnetic hyperthermia for improving antitumor therapeutic efficacy. Theranostics, 2020, 10(8): 3793-3815. IF= 8.063 SCI一区

3. Yao Li#, Xiao Zhao#, Xiaoli Liu#, Keman Cheng, Xuexiang Han, Yinlong Zhang, Huan Min, Guangna Liu, Junchao Xu, Jian Shi, Hao Qin, Haiming Fan,* Lei Ren,* and Guangjun Nie*. A Bioinspired Nanoprobe with Multilevel Responsive T1-Weighted MR Signal-Amplification Illuminates Ultrasmall Metastases. Advanced Materials, 2020, 32(4): 1906799. IF=25.806 SCI一区

2019

1. Xiaoli Liu#, Shizhu Chen#, Huan Zhang, Jin Zhou, Haiming Fan*, Xing-Jie Liang*. Magnetic nanomaterials for advanced regenerative medicine: The promise and challenges. Advanced Materials, 2019, 31(45): 1804922. IF=25.806 SCI一区

2.Xiaoli Liu,#Mingli Peng,# Galong Li,# Yuqing Miao, Hao Luo, Guangyin Jing, Yuan He, Ce      Zhang, Fan Zhang, and Haiming Fan*. Ultrasonication-triggered ubiquitous assembly      of magnetic Janus amphiphilic nanoparticles in cancer theranostic applications.      Nano      Letters, 2019, 19(6), 4118-4125. IF=12.279 SCI一区

3.Xiaoli Liu#,Jianjun Zheng#, Wei Sun#, Xiao Zhao#, Yao Li, Ningqiang Gong, Yanyun Wang,      Xiaowei Ma, Tingbin Zhang, Ling-Yun Zhao, Yayi Hou, Zhibing Wu, Yang Du*,      Haiming Fan*, Jie Tian*, Xing-Jie Liang*. Ferrimagnetic vortex      nanoring-mediated mild magnetic hyperthermia imparts potent immunological      effect for treating cancer metastasis. ACS Nano, 2019,      13(8), 8811-8825. IF=13.903 SCI一区

4.Wei Zhang#, Yan Wen#, Dong-Xuan He, Yi-Feng Wang, Xiao-Li Liu*, Chan Li,* and Xing-Jie Liang*. Near-infrared      AIEgens as transformers to enhance tumor treatment efficacy with controllable      self-assembled redox-responsive carrier-free nanodrug. Biomaterials,      2019, 193, 12-21. IF=10.273 SCI一区

5.Yang Du#, Xiaoli Liu#, Qian      Liang#, Xing-Jie Liang*, Jie Tian*. Optimization and design of magnetic      ferrite nanoparticles with uniform tumor distribution for highly sensitive      MRI/MPI performance and improved magnetic hyperthermia therapy. Nano      Letters, 2019, 19(6), 63618-3626. IF=12.279 SCI一区

6. Xiaowei Ma#, Yanyun Wang#, Xiao-Li Liu#, Huijun Ma, Galong Li, Yao Li, Fei Gao, Mingli Peng, Hai Ming Fan* and Xing-Jie Liang*. Fe3O4-Pd Janus nanoparticles with amplified dual-mode hyperthermia and enhanced ROS generation for breast cancer treatment. Nanoscale Horizons, 2019, 4, 1450-1459. IF=9.095 SCI一区

7.Pon Janani Sugumaran#, Xiao-Li Liu#,      Tun Seng Herng, Erwin Peng, Jun Ding*. GO-functionalized large magnetic iron      oxide nanoparticles with enhanced colloidal stability and hyperthermia performance.      ACS      Applied Materials & Interfaces, 2019, 11, 22703-22713.      IF=8.456 SCI一区

2018

1. Y. B. Lv#, P. Chandrasekharan#, Y. Li#, X. L. Liu*, J. P. Avila, Y. Yang, K. H. Chuang, Xing-Jie Liang, J. Ding*. Magnetic resonance imaging quantification and biodistribution of magnetic nanoparticles using T1-enhanced contrast. J. Mater. Chem. B., 2018, 6: 1470-1478. IF=5.047

2. V. Kalidasan#, X. L. Liu#*, Y. Li#, P. J. Sugumaran, A. H. Liu, L. Ren, and J. Ding*. Examining the effect of ions and proteins on the heat dissipation of iron oxide nanocrystals. RSC Advances, 2018, 8, 1443-1450. IF=3.049

2012-2017

1. Xiaoli Liu, Yong Yang, Cheng Teng Ng, Lingyun Zhao, Ying Zhang, Boon Huat Bay, Haiming Fan* and Jun Ding*. Magnetic vortex nanorings: A new class of hyperthermia agent for highly efficient in vivo regression of tumors. Advanced Materials, 2015, 27(11), 1939-1944. IF=25.806

2. Xiaoli Liu#, Cheng Teng Ng#, Prashant Chandrasekharan, Haitao Yang, Lingyun Zhao, Erwin Peng, Yunbo Lv, Wen Xiao, Jie Fang, Jiabao Yi, Huan Zhang, Kai-Hsiang Chuang, Boon Huat Bay, Jun Ding*, and Hai Ming Fan*. Synthesis of ferromagnetic Fe0.6Mn0.4O nanoflowers as a new class of magnetic theranostic platform for in vivo T1‐T2 dual‐mode magnetic resonance imaging and magnetic hyperthermia therapy. Advanced Healthcare Materials, 2016, 5(16): 2092-2104. IF=6.27

3. Xiaoli Liu, Yutong Wang, Chengteng Ng, Rong Wang, Guangyin Jin, Jiabao Yi, Jian Yang, Boonhuat Bay, Linyue Lanry Yung, Daidi Fan, Jun Ding, Haiming Fan*. Coating engineering of MnFe2O4 nanoparticles with superhigh T2 relaxivity and efficient cellular uptake for highly sensitive magnetic resonance imaging. Advanced Materials Interfaces, 2014, 1(2), 1300069. IF=4.713

4. Xiaoli Liu, Huan Zhang, Le Chang, Baozhi Yu, Qiuying Liu, Jianpeng Wu, Yuqing Miao, Pei Ma, Daidi Fan* and Haiming Fan*. Human-like collagen protein-coated magnetic nanoparticles with high magnetic hyperthermia performance and improved biocompatibility. Nanoscale Research Letters, 2015, 10(1), 1-8. IF=3.156

5. Xiaoli Liu, Yong Yang, Jianpeng Wu, Yifan Zhang, Haiming Fan and Jun Ding*. Novel magnetic vortex nanorings/nanodiscs: Synthesis and theranostic applications. Chinese Physics B, 2015, 24(12), 127505. IF=1.469

6. Xiao Li Liu, Eugene Shi Guang Choo, Anansa S. Ahmed, Ling Yun Zhao, Yong Yang, Raju V. Ramanujan, Jun Min Xue, Dai Di Fan, Hai Ming Fan*, and Jun Ding*. Magnetic nanoparticles-loaded polymer nanospheres as magnetic hyperthermia agent. J. Mater. Chem. B., 2014, 2, 120-128. IF=5.047

7. Xiao Li Liu, Hai Ming Fan*. Innovative magnetic nanoparticle platform for magnetic resonance imaging and magnetic fluid hyperthermia application. Curr. Opin. Chem. Eng., 2014, 4, 38-46. (Invited review) IF=4.463

8. Xiao Li Liu, Hai Ming Fan*, Jia Bao Yi, Yang Yang, Eugene Shi Guang Choo, Jun Min Xue, Dai Di Fan and Jun Ding*. Optimization of surface coating on Fe3O4 nanoparticles for high performance magnetic hyperthermia agents. J. Mater. Chem. 2012, 22, 8235-44. IF=5.047

9. Le Chang, Xiao Li Liu*, Yu Qing Miao, Dai Di Fan*, Huan Zhang, He Ping Ma, Qiu Ying Liu, Pei Ma, Wei Ming Xue, Yan E Luo, and Hai Ming Fan*. The efficiency of magnetic hyperthermia and in vivo histocompatibility for human-like collagen protein coated magnetite nanoparticles. Int. J. nanomedicine, 2016, 11, 1175-1185. IF=4.471

10. Baozhi Yu,# Xiaoli Liu,# Huigang Zhang, Guangyin Jing, Pei Ma, Yane Luo, Weiming Xue, Zhaoyu Ren* and Haiming Fan*. Fabrication and structural optimization of porous single-crystal α-Fe2O3 microrices for high-performance lithium-ion battery anodes. J. Mater. Chem. A., 2015, 3(32), 16544-16550. IF=10.733

11. Weiming Xue#, Xiaoli Liu#, Heping Ma, Wensheng Xie, Saipeng Huang,  Huiyun Wen,  Guangyin Jing,  Lingyun Zhao, Xingjie Liangc and  Haiming Fan*. AMF responsive DOX-loaded magnetic microspheres: Transmembrane drug release mechanism and multimodality postsurgical treatment of breast cancer. Journal of Materials Chemistry B, 2018, 6(15):2289-2303. IF=5.047

12. Xiaoli Liu, Minrui Zheng, Yunbo Lv, Jie Fang, Chorng Haur Sow, Haiming Fan, Jun Ding*. Large-scale synthesis of high-content Fe nanotubes/nanorings with high magnetization by H2 reduction process. Materials Research Bulletin, 2013, 48, 5003-5007. IF=3.355

13. Yifan Zhang, Xiaoli Liu*, Erwin Peng, Galong Li, Wen Xiao, Huan Zhang, Baozhi Yu, Jianpeng Wu, Yane Luo, Haiming Fan*. Facile synthesis of water-dispersible magnetite nanorings from surfactant-free hematite nanorings. Micro & Nano Letters, 2016, DOI: 10.1049/mnl.2016.0304. IF=0.975

14. Yan Wen#, Yingze Wang#, Xiaoli Liu*, Wei Zhan, Xinhe Xiong, Zhongxiao Han, Xingjie Liang*. Camptothecin-based nanodrug delivery systems. Cancer Biol Med, DOI: 10.20892/j.issn.2095-3941.2017. IF=4.467

近日,赌钱平台官网刘晓丽教授与樊海明教授首次提出了一种新型的磁热动力疗法(Magnetothermodynamic therapy, MTD),该疗法突破传统磁热疗的局限性,将纳米氧化铁的磁感应热效应和其诱导ROS相关的免疫效应相结合,有效抑制肿瘤生长。该MTD的提出有力的促进了传统MTT的发展,克服了其仅依赖于热效应的不足,深化了对纳米氧化铁介导的磁热疗的理解,通过联合ROS介导的免疫效应,不仅显著提高抗肿瘤疗效,还为将来精准、高效的纳米磁治疗提供了新的思路。

癌症转移是导致其治疗失败的一个主要原因。报道了一种有效安全的纳米磁热治疗策略,可以根除原发性肿瘤,并抑制其肺部转移,进而控制远处肿瘤的转移和生长。

Xiaoli Liu, et al. ACS Nano 2019, 13, 8811-8825


刘晓丽教授在生物医学1区杂志《Theranostics》(2020 IF: 8.063) 上发表了题为“Comprehensive understanding of magnetic hyperthermia for improving antitumor therapeutic efficacy”的综述


一种简单、普适的方法,可按诊疗应用需求设计制备多种高效的磁性Janus双亲颗粒。

Xiaoli Liu, et al. Nano Lett. 2019, 19, 4118-4125

全面、系统概述了磁性纳米颗粒在再生医学的应用前景及挑战。

Xiaoli Liu,et al. Adv. Mater. 2018, DOI: 10.1002/adma.201804922