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教师简介

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魏岱旭

个人简介

魏岱旭,男,33岁,四川自贡人,赌钱平台官网赌钱平台官网教授,陕西省普通高校杰出青年人才支持计划入选者。团队长期从事天然生物材料、合成生物学、组织工程与再生医学、医用纳米技术、肠道微生物与微生态、生物力学与空间生物学的研究工作。在Advanced materials、SMALL、ACS Applied Materials & Interface、Nanomedicine等国际学术期刊上共发表SCI学术论文24篇,获得授权专利16项,参与主编学术专著1本,主持国家级科研项目1项,参与国家级科研项目2项,参与地方省部级科研项目1项。
首创“细胞微型方舟”(Micro-Ark of Cells,MAC)系统。曾参与中国航天重大项目“天舟一号”科学实验,相关科研事迹登上《中国日报》海外版(China Daily)、中国中央电视台《早间新闻》和《走近科学》等主流媒体。现为中国生物材料学会会员、中国化学学会会员、热心肠智库专家成员、北京蓝晶微生物科技公司科学顾问、十大赌博官方正规网站iGEM(国际基因工程机器大赛)团队指导老师。

承担的科研项目

参与课题和在研项目:
1. 国家自然科学基金青年项目,31900950,可注射天然聚酯支架的仿生功能设计及医美微整形骨修复研究,2020/01-2022/12,23万元,在研,主持
2. 国家高技术研究发展计划(863计划),2013AA032203,生物相容性纳米组织修复材料研制及应用,2013/06-2015/06,1152万元, 已结题,参与
3. 上海浦江人才计划,12PJ1430300,万能力学试验机-原子力显微镜联用系统研制及其应用研究,20万,已结题,参与
4. 国家自然科学基金青年项目,81202471,基于神经毡蛋白-1介导神经胶质瘤靶向的脂质体递药系统研究,2013/01-2015/01,23万元,已结题,参与

主要研究方向:
1. 合成生物学与医学治疗。以合成生物学和工程化微生物为核心,对医用级天然生物材料进行结构设计及复合加工,开发出有效的临床治疗手段解决组织创伤修复,器官重建与移植,退行性疾病治疗等重大医学问题。 近几年,侧重于微生物来源天然聚酯与胶原蛋白的研究和应用。
2. 组织工程与再生医学。天然生物材料为核心,探索不同尺寸、不同功能、不同形态的医学组织工程载体/支架的制备技术及医用材料的界面修饰技术,从微观拓扑及生物功能双重角度研究医用载体(或支架)与干细胞(或药物)的相互作用,探索与骨、软骨、肌腱、神经、心肌等受损组织的修复和功能再造的作用和新技术。近几年,侧重于球型组织工程与Polymer-PhaP-X(PPX)系统的研究和应用。
3. 微纳米器件与医疗美容。微创手术器械与医疗美容的研发与改良,主要涉及可注射型医学材料改良、用于皮肤修复和皮肤用抗菌消炎材料的制备与器件研发。
4. 纳米技术与肠道微生物菌群。以肠道微生物菌群为核心,探索纳米技术与纳米材料对肠道微生态的影响,开放合理的肠道治疗方法。
5. 生物力学与空间生物学。对比研究重力环境和(模拟)太空环境下,微生物/细胞的行为学及分子水平差异,开发微重力或宇宙辐射等极端环境下人体修复的新技术。

主要研究成果

代表性论文:
1. Daixu Wei,Jinwei Dao,Guo-Qiang Chen*. A Micro-Ark for Cells: Highly Open Porous Polyhydroxyalkanoate Microspheres as Injectable Scaffolds for Tissue Regeneration. Advanced Materials. (2018): 1802273. (第一作者,IF=25.809)
2. Daixu Wei,Ruirui Qiao,Jinwei Dao,Jing Su,Chengmin Jiang,Xichang Wang,Mingyuan Gao,Jian Zhong*. Soybean Lecithin-Mediated Nanoporous PLGA Microspheres with Highly Entrapped and Controlled Released BMP-2 as a Stem Cell Platform. SMALL. 2018. 14(22): 1800063. (第一作者,IF=10.856)
3. Dai-Xu Wei,Jin-wei Dao Hua-wei Liu* Guo-Qiang Chen*. Suspended Polyhydroxyalkanoate Microspheres as 3D Carriers for Mammalian Cell Growth. 2018: 1-11. Artificial Cells Nanomedicine and Biotechnology. (2018): 1-11. (第一作者,IF=4.462)
4. Dai-Xu Wei,Chong-Bo Chen,Guo Fang,Shi-Yan Li,Guo-Qiang Chen*. Application of polyhydroxyalkanoate binding protein PhaP as a bio-surfactant. Appl Microbiol Biotechnol. 2011;91:1037-47. (第一作者,IF=23.67)
5. Yunsong Yan,Daixu Wei*,Jiayan Li,Jinhong Zheng,Ganggang Shi,Wenhong Luo,Ying Pan,Jinzhi Wang,Lumian Zhang,Xiaoying He,Daojun Liu,A poly(L-lysine)-based hydrophilic star block co-polymer as a protein nanocarrier with facile encapsulation and pH-responsive release. Acta biomaterialia. 2012;8:2113-20. (共同一作&共同通讯,IF=6.638)
6. Liu X,Wei D,Zhong J,Ma M,Zhou J,Peng X,et al. Electrospun Nanofibrous P (DLLA–CL) Balloons as Calcium Phosphate Cement Filled Containers for Bone Repair: in Vitro and in Vivo Studies. ACS applied materials & interfaces. 2015;7:18540-52. (共同一作,IF=8.456)
7. Gang Sun,Daixu Wei,Xunwei Liu,Yuyun Chen,Min Li,Dannong He,Jian Zhong. Novel Biodegradable Electrospun Nanofibrous P(DLLA-CL) Balloons for the Treatment of Vertebral Compression Fractures. Nanomedicine. 2013;9(6):829-38. (共同一作,IF=4.717)
8. Pei P,Wei D,Zhu M,Du X,Zhu Y. The effect of calcium sulfate incorporation on physiochemical and biological properties of 3D-printed mesoporous calcium silicate cement scaffolds. Microporous and Mesoporous Materials. 2016. 241: 11-20(共同一作,IF=4.182)
9. Hua-wei LIU,Dai-xu WEI*,Ming NI,Yong-gang ZHOU*,Combined antibacterial and osteogenic in situ effects of a bifunctional titanium alloy with nanoscale hydroxyapatite coating. Artificial Cells Nanomedicine and Biotechnology. (共同一作,IF=4.462)
10. Du, X., Wei, D., Huang, L., Zhu, M., Zhang, Y., & Zhu, Y.. 3D printing of mesoporous bioactive glass/silk fibroin composite scaffolds for bone tissue engineering. Materials Science and Engineering: C 103 (2019): 109731. (共同一作,IF=4.959)
11. YueFeng Rui,Jingquan Liu*,Bin Yang,Chunsheng Yang,Daixu Wei*. Mechanical and electrical stability of parylene-based platinum-black coated wire microelectrode for implantable applications. J Appl Electrochem. 2013;43(3):301-308.
12. Yu,J.,Xu,L.,Xie,N.,Li,K.,Xi,Y.,Liu,X.,... & Wei,D. Optimal Zn-Modified Ca–Si-Based Ceramic Nanocoating with Zn Ion Release for Osteoblast Promotion and Osteoclast Inhibition in Bone Tissue Engineering[J]. Journal of Nanomaterials,2017.
13. Jiangming Yu1,Ning Xu,Yanhai Xi,Mintao Xue,Weiheng Wang,Xiaodong Huang,Changkun Zheng,Daixu Wei,*,Kai Li,*,Xiaojian Ye,*.Adhesion behavior of Escherichia coli on plasma-sprayed Zn and Ag co-incorporated calcium silicate coatings with varying surface roughness. J Thermal Spray Technology, 2018, 27(8): 1428-1435.
14. Xue-mei CHE,Dai-Xu Wei,Guo-Qiang Chen*. Superhydrophobic Polyhydroxyalkanoates: Preparation and Applications. Biomacromolecules.2018.
15. Qing Lu,Daixu Wei,Jiejun Cheng,Jianrong Xu,Jun Zhu*. A novel contrast agent with rare earth-doped up-conversion luminescence and Gd-DTPA magnetic resonance properties. Journal of Solid State Chemistry. 2012;192(8): 75-80.
16. Zhu,Jun,Lu,Qing,Wei,Daixu,Zhou,Juan,Cheng,Jiejun,Xu,Jianrong. Preparation of Polymer-Functionalized Iron Oxide Nanoparticles and Their Biomedical Properties. Chinese Journal of Chemistry. 2013,31(3): 401-6.
17. Jian Zhong*,Mengjia Ma,Juan Zhou,Daixu Wei,Zhiqiang Yan,Dannong He. Tip-Induced Micropatterning of Silk Fibroin Protein Using In Situ Solution Atomic Force Microscopy. ACS Appl. Mater. Interfaces,2013,5 (3),pp 737–746.
18. Xu N,Ye X,Wei D,Zhong J,Chen Y,Xu G,He D. 3D artificial bones for bone repair prepared by computed tomography-guided fused deposition modeling for bone repair. ACS Appl Mater Interfaces. 2014;6(17):14952-63.
19. Ma Y,Li J,Yao Y,Wei D,Wang R,Wu Q. A controlled double-duration inducible gene expression system for cartilage tissue engineering. Scientific reports. 2016;6:26617.
20. Ma YM,Wei DX,Yao H,Wu LP,Chen GQ. Synthesis,Characterization and Application of Thermoresponsive Polyhydroxyalkanoate-graft-Poly (N-isoprop-ylacrylamide). Biomacromolecules. 2016;17:2680-90.
21. Zhou XH,Wei DX,Ye HM,Zhang X,Meng X,Zhou Q. Development of poly(vinyl alcohol) porous scaffold with high strength and well ciprofloxacin release efficiency. Materials science & engineering C,Materials for biological applications. 2016;67:326-35.
22. Yao H,Wei D,Che X,et al. Comb-like temperature-responsive polyhydroxyalkanoate-graft-poly (2-dimethylamino-ethylmethacrylate) for controllable protein adsorption. Polymer Chemistry,2016,7(38): 5957-5965.
23. Yan Z,Yang Y,Wei X,Zhong J,Wei D,Liu L,Xie C,Wang F,Zhang L,Lu W and others. Tumor-penetrating peptide mediation: an effective strategy for improving the transport of liposomes in tumor tissue. Mol Pharm 2014;11(1):218-25.
24. Yang Y,Yan Z,Wei D,Zhong J,Liu L,Zhang L,Wang F,Wei X,Xie C,Lu W and others. Tumor-penetrating peptide functionalization enhances the anti-glioblastoma effect of doxorubicin liposomes. Nanotechnology 2013;24(40):405101.

专著情况:
1. 陈国强,魏岱旭 主编.《微生物聚羟基脂肪酸酯》. 化学工业出版社. 2014年.

授权专利情况:
1. 魏岱旭;闫志强;钟建;周涓;朱君;何丹农,一种负载羟基磷灰石的聚乳酸多孔微球及制备方法,中国,CN201210396694.6,2014.05.07
2. 魏岱旭;闫志强;钟建;何丹农,一种生物可降解高分子多孔尿道修复支架及制备方法,中国,CN201110436651.1,2013.06.26
3. 魏岱旭;钟建;闫志强;何丹农,一种多孔膜片及制备方法和应用,中国,CN201110436623.X,2013.06.26
4. 激光共聚焦扫描显微镜高分子纤维可视化的制备方法,中国,CN201110436614.0,魏岱旭;钟建;闫志强;何丹农,2013.06.26
5. 魏岱旭;钟建;何丹农;多层结构的神经修复导管支架及其制备方法,中国CN201310639284.4,2014.03.26
6. 魏岱旭;马梦佳;周涓;施丽君;钟建;何丹农,一种混合型蛋白质生物表面活性剂的石化类油乳化方法,中国 CN201310265021.1,2013.10.23
7. 陈国强;魏岱旭,两亲性蛋白—聚羟基脂肪酸酯颗粒结合蛋白PhaP的新用途,中国 CN201110007851.5, 2013.09.27
8. 马梦佳;魏岱旭;钟建;闫志强;余震;何丹农,一种静电纺丝复合血管支架及其制备方法,中国 CN201210270606.8,2012.11.07
9. 钟建;魏岱旭;周涓;何丹农,原子力显微镜配套用卧式材料拉伸压缩试验机,中国,CN201310751692.9,2014.04.30
10. 马梦佳;魏岱旭;钟建;闫志强;余震;何丹农;一种新的静电纺丝复合支架及其制备方法,中国 CN201210269929.5,2012.12.26
11. 周涓;施丽君;魏岱旭;朱君;何丹农;一种水溶性丝素粉及其制备方法,中国 CN201210397390.1,2014.05.07
12. 刘璐;魏岱旭;朱君;王丹,一种低表面张力的载氧脂质体及其制备方法,中国 CN201310438079.1,2014.01.15
13. 闫志强;杨一祎;魏岱旭;钟建;刘璐;金彩虹;何丹农,一种聚乳酸-聚乙二醇-肿瘤穿透肽复合物及制备和应用,中国 CN201310437613.7,2014.01.29
14. 钟建;马梦佳;魏岱旭;闫志强;周涓;李文英;何丹农;单分子力谱分析用AFM探针和基底功能化修饰方法,中国 CN201210258572.0,2014.02.12
15. 闫志强;杨一祎;魏岱旭;钟建;何丹农,一种D型多肽介导的靶向脂质体及其制备方法和应用,中国 CN201210383701.9,2014.04.16
16. 马梦佳;李文英;钟建;魏岱旭;闫志强;余震;何丹农,一种简单的磁颗粒功能化修饰方法,中国 CN201210269926.1,2012.07.31

魏岱旭

所属部门: 教师
职称:教授
荣誉:
研究方向:
电子邮件: weidaixu@nwu.edu.cn