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田静

个人简介

田静,博士,十大赌博官方正规网站生命科学学院教授,博士生导师。

2006年在新加坡国立大学获得发育生物学博士学位;随后在新加坡淡马锡生物实验室任研究员,从事胚胎早期发育的研究(2006-2008);在新加坡生物医学研究所任高级研究员,主要从事人类遗传疾病研究(2008-2013)。

通信地址:十大赌博官方正规网站生命科学学院,西安市太白北路229号,邮编:710069

E-mail: tianjing@nwu.edu.cn

电话: 029-88302339

承担的科研项目

主要研究方向:人类罕见遗传疾病;与骨骼发育相关的遗传疾病;与癌症相关的遗传疾病;斑马鱼早期胚胎发育

为了更深入了解人类正常胚胎发育的基础,课题组主要研究先天性出生缺陷及不正常表型的遗传性疾病。罕见遗传疾病往往由单基因突变造成,虽然远远少于多基因突变疾病,但对每一种单基因突变遗传疾病的研究可使我们更深入了解治病基因的分子机制,为进一步了解多基因突变疾病提供了坚实的基础。其研究是从人类罕有的家族谱系开始,首先利用全基因组序列分析找到引起该罕见遗传疾病的致病基因。在此基础上,通过使用各种动物模型,如人原代细胞,果蝇、斑马鱼、小鼠等,并结合分子遗传学、发育生物学、细胞生物学、蛋白质组学以及系统生物学等手段,对该致病基因的功能进行详细的研究,从而掌握该基因的致病机理,为该疾病的预防、临床诊断、治疗以及新药的开发提供理论依据。目前实验室主要进行短指症、并指症、独指症、颅缝早闭症等罕见遗传病的研究。

主要研究成果

代表性论文:

1.Perez-Camps M, Tian J, Chng S,Sem KP, Sudhaharan T, The
C, Wachsmuth M, Korzh V, Ahmed S, Reversade
B. (2016) Quantitative imaging reveals real-timePou5f3–Nanog complexes
drivingdorsoventralmesendoderm patterning inzebrafish. eLIFE5:e11475.

2. Chng S,
Ho L, Tian J,Reversade B. (2013)
ELABELA: a hormone essential for heart development signals via the Apelin
receptor. Developmental Cell.27(6):672-680.

3. Temtamy
S*, Aglan M*, Topaloglu AK, Wollnik B, Amr K, El-Badry TH, Hosny GA, Eldin NS,
Shboul M, Herdem M, Ong J, Reversade B,
Tian, J*. (2012) Definition of the phenotypic spectrum of
Temtamypreaxialbrachydactyly syndrome associated with autosomal recessive CHYS1
mutations.Middle East Journal of Medical Genetics. 1(2):64-70.

4.Tian J, Ling L, Shboul M, Lee H,
O'Connor B, Merriman B, Nelson SF, Cool S, Ababneh OH, Al-Hadidy A, Masri A,
Hamamy H, Reversade B. (2010) Loss of CHSY1, a Secreted FRINGE Enzyme, Causes
Syndromic Brachydactyly and Increased NOTCH Signaling in Humans. The
American Journal of Human Genetics. 87:768-778.

5.Tian J, Andree B, Jones C.M. and
Sampath K. (2008) The pro-domain of the zebrafish Nodal-related protein Cyclops
regulates its signaling activities. Development. 135:2649-58.

6.Tian J, and Sampath, K. (2004)
Formation and Functions of the floor plate. Fish Development and Genetics.World
Scientific. Editors: Z. Gong and V. Korzh.

7. Tian J, Yam C, Balasundaram G, Wang H,
Gore A and Sampath K. (2003) A temperature-sensitive mutation in the
nodal-related gene cyclops reveals that the floor plate is induced during
gastrulation in zebrafish.Development. 130: 3331-3342.

国际会议报告论文:

1.Tian J,Shboul M,Hamammy H,Reversade
B,Dubowitz Syndrome mapsto chromosome 12 within an interval of 70
genes,16th International Society of Developmental BiologistsCongress,Edinburg,UK , 2009

2.Tian J,Ling L,Shboul M,Reversade
B,Loss ofCHSY1, a novel FRINGE Enzyme, causes Syndromic Brachydactyly
via IncreasedNotch signaling,The
16th International Conference of the International Societyof Differentiation
From Stem Cells toOrganisms,Nagoya, Japan,,2010

3.Tian J ,Chng S,Ong JX,Reversade B,Cloning and functional study of nanog in Zebrafish,Society for Developmental Biology 70th Annual Meeting, Chicago,USA,2011

4.Tian J,TemtamyPreaxialBrachydactyly Syndrome is
caused by loss-of-function of CHSY1, a secreted enzyme required for bone
development and digit patterning, 6th Asia Oceania Zebrafish Meeting, HKUST, Hong Kong, 2014 (大会报告)

5.TianJ,Mechanisms of Digit Formation : Rare Human
Malformation Syndromes Tell theStory, 47th Annual Meeting of the Japanese
Society of Developmental Biologists, Nagoya, Japan, 2014 (大会报告)

6.Tian J ,Cenani-Lenz
syndrome is caused by a novel missensemutation in LRP4 that required for limb
and kidney development,The 7th AsiaOceania Zebrafish Meeting,Singapore,2016

田静

所属部门: 教师
职称:教授
荣誉: 博士生导师
研究方向:
电子邮件: tianjing@nwu.edu.cn